Centre for Integrative Genetics

Two papers on “milk genetics”

Olsen HG, Knutsen TM, Kohler A, et al. Genome-wide association mapping for milk fat composition and fine mapping of a QTL for de novo synthesis of milk fatty acids on bovine chromosome 13. Genet Sel Evol. 2017. doi:10.1186/s12711-017-0294-5.

Ketto IA, Knutsen TM, Øyaas J, et al. Effects of milk protein polymorphism and composition, casein micelle size and salt distribution on the milk coagulation properties in Norwegian Red cattle. Int Dairy J. 2016. doi:10.1016/j.idairyj.2016.10.010.


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Salmon genome sequence published in Nature

Homeologous regions in the Atlantic salmon genome

Eighty million years ago, a mutant fish was born that turned out to be very successful. This mutant had a double set of hereditary material – 50 chromosomes instead of the usual 25 – and it became the ancestor of all the salmonid fishes. A lot has happened during the course of this speciation and diversification: chromosomes have split up and been jumbled around, and many gene duplicates have been lost. But even today, about half of salmon genes exist in two copies, possibly linked to the ecological flexibility of salmonids. The CIGENE team have driven the sequencing of the salmon genome from its inception to its recent publication in Nature. Continue reading “Salmon genome sequence published in Nature”

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New cod related pre-prints out on bioRxiv –

Two new papers out now on bioRxiv.

One identifying the sex determination locus in Atlantic cod:

The other describing a chromosomal rearrangement associated with migration:


Transposable elements (TEs) are abundant, mobile DNA sequences whose behavior can have profound evolutionary impacts. Recent research has shown that they can modify gene regulation and drive structural rearrangements of chromosomes. Despite half a century of investigation, fundamental questions remain unanswered about the evolutionary consequences of TE activity, the evolutionary forces determining the distribution of TEs across taxa, and the frequency with which TEs are co-opted by natural selection to increase fitness and create adaptive innovations. Continue reading “Transpose”


The premise for all natures magnificent variation in species, life strategies and adaptations is differences in the DNA code. These genetic differences can be traced back to the sequence of the code, how DNA is organized into chromosomes and, ultimately, how the code is used to produce proteins in each cell type. Hence, if we wish to understand how new adaptations and species arise, we need to understand how new DNA-variation arise through mutations and how these novel variations in the DNA-code gives rise to new functions.

  Continue reading “Rewired”


GENEInnovate (9MNOK, Norges forskningsråd)

Norwegian breeding companies focusing on cattle, pigs, salmon and plants offer genetic material (germ cells; sperm, eggs, and seeds) in a highly competitive, global market and are under constant pressure to develop new, innovative products demanded by growers, food manufacturers, and consumers. Traditional methods for breed/strain improvement are relatively slow and imprecise, and are constrained in that they can only build upon genetic variation already existing in the companies breeding core. Continue reading “GENEinnovate”

Med kart og kompass blant gener og aminosyrer

Vår masterstudent Filip Rotnes beskriver hverdagen i et biokjemisk reaksjonsnettverk!


CIGENE acquires funding for 4 large research projects

CIGENE members have acquired funding for four large new projects over the past months.

  • Sigbjørn Lien got funded a TOPPFORSK Fripro project on the impact of transposable elements on salmonid evolution and adaptation (Funded by Norwegian research council)
  • Simen Rød Sandve got funded Fripro Young Research Tallents project on adaptive consequences of whole genome duplication (Funded by Norwegian research council)
  • Matthew Kent will lead a project on gene editing to innovate breeding (Co-funding between industry and Norwegian research council)
  • Dag Inge Våge will lead the NMBU-node of the Norwegian ELIXIR project (Funded through EU)

Congratulations to everyone involved!

CIGENE member wins NMBU research award

CIGENE researcher Simen Sandve wins the NMBU research award 2017. Congrats!



Podcast: Anvendt science fiction

Two new papers accepted in Genome Biology and Nature Genetics

CIGENE researchers have contributed to two new papers on genome evolution after whole genome duplication, one published in Genome biology and one accepted for publication in Nature Genetics!

Congrats Fabian, Sigbjørn, Torgeir, and Simen!




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