GenoSysFat

Integrating genomics and system biology to improve the capacity for synthesis, transport, and filet deposition of EPA/DHA in salmon

Summary:
A major challenge for Norwegian aquaculture is to maintain a healthy and high content of very long omega-3 (i.e. EPA/DHA) when the salmon is fed diets containing limited fish oil. This challenge can be met both by optimizing diet and feeding regimes and by breeding for higher capability to synthesize, transport and deposit EPA/DHA in the muscle. In this application we propose to combine these two strategies in a integrative approach that utilize detailed knowledge of the salmon genome together with detailed understanding of the salmon body as a metabolic system that transforms feed into filet.

Using the novel salmon genomic sequence and modern systems biological methods, we will clarify the genotype-by-diet interaction through a combination of feeding experiments, laboratory culture of thin slices of liver (which synthesizes fatty acids), and mathematical analysis and modeling. In particular, gene expression data from experiments can be interpreted in light of the detailed map of the duplicated salmon genome, a detailed map of the biochemical reaction pathways, and mathematical descriptions of how the salmon body functions as a system. In the long term, the project will enable the rapid design of salmon feeds as new feedstuffs become available or prices shift, and targeted selection and breeding of salmon that are healthy to eat and grow well on modern feeds.

Project home page: GenoSysFat – Integrating genomics and systems biology to improve the capacity for synthesis, transport, and filet deposition of EPA/DHA in salmon

CIGENE researchers involved: